The New England journal of medicine | Volume 350 of Issue 12
Authors: Strewler GJ
American journal of epidemiology
Authors: Simon JA, Murtaugh MA, Gross MD, Loria CM, Hulley SB, Jacobs DR
Archives of internal medicine
Authors: Kizer JR, Zisman DA, Blumenthal NP, Kotloff RM, Kimmel SE, Strieter RM, Arcasoy SM, Ferrari VA, Hansen-Flaschen J
Bioorganic & medicinal chemistry letters | Volume 14 of Issue 5
Authors: Stearns BA, Anker N, Arruda JM, Campbell BT, Chen C, Cramer M, Hu T, Jiang X, Park K, Ren KK, Sablad M, Santini A, Schaffhauser H, Urban MO, Munoz B
A novel class of 6-aryl-6H-pyrrolo[3,4-d]pyridazine ligands for the alpha2delta subunit of voltage-gated calcium channels has been described. Substitutions in the aryl ring of the molecule were generally not tolerated, and resulted in diminished binding to the alpha2delta subunit. Modifications to the pyridazine ring revealed numerous permissive substitutions, and detailed SAR studies were carried out in this portion of the molecule. Replacement of the pyridazine ring methyl group with an aminomethyl functionality provided greatly improved potency over the initial lead. The initial lead compound displayed good rat pharmacokinetic properties, and was shown to be efficacious in the Chung model for neuropathic pain in rats.
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Journal of the American College of Cardiology | Volume 43 of Issue 5
Authors: Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, Grady D, Haan CK, Hayes SN, Judelson DR, Keenan NL, McBride P, Oparil S, Ouyang P, Oz MC, Mendelsohn ME, Pasternak RC, Pinn VW, Robertson RM, Schenck-Gustafsson K, Sila CA, Smith SC, Sopko G, Taylor AL, Walsh BW, Wenger NK, Williams CL, American Heart Association , American College of Cardiology , American College of Nurse Practitioners , Amercian College of Obstetricians and Gynecologists , American College of Physicians , American Medical Women's Association , Association of Black Cardiologists , Centers for Disease Control and Prevention , National Heart, Lung and Blood Institute, National Institutes of Health , Office of Research on Women's Health , Sociey of Thoracic Surgeons , World Heart Federation
The American journal of geriatric cardiology
Authors: Shlipak MG, Fried LF, Stehman-Breen C, Siscovick D, Newman AB
Hepatology (Baltimore, Md.)
Authors: Monto A, Patel K, Bostrom A, Pianko S, Pockros P, McHutchison JG, Wright TL
Annals of neurology | Volume 24 of Issue 3
Authors: Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL
Arteriosclerosis, thrombosis, and vascular biology | Volume 24 of Issue 3
Authors: Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, Grady D, Haan CK, Hayes SN, Judelson DR, Keenan NL, McBride P, Oparil S, Ouyang P, Oz MC, Mendelsohn ME, Pasternak RC, Pinn VW, Robertson RM, Schenck-Gustafsson K, Sila CA, Smith SC, Sopko G, Taylor AL, Walsh BW, Wenger NK, Williams CL, AHA
Policy brief (UCLA Center for Health Policy Research)
Authors: Brown ER, Lavarreda SA, Meng YY, Andersen RM, Bindman AB, Gelberg L, Becerra L, Gatchell M, Yoon J