PLoS pathogens | Volume 16 of Issue 11
Authors: Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA
It is unclear what mechanisms govern latent HIV infection in vivo or in primary cell models. To investigate these questions, we compared the HIV and cellular transcription profile in three primary cell models and peripheral CD4+ T cells from HIV-infected ART-suppressed individuals using RT-ddPCR and RNA-seq. All primary cell models recapitulated the block to HIV multiple splicing seen in cells from ART-suppressed individuals, suggesting that this may be a key feature of HIV latency in primary CD4+ T cells. Blocks to HIV transcriptional initiation and elongation were observed more variably among models. A common set of 234 cellular genes, including members of the minor spliceosome pathway, was differentially expressed between unstimulated and activated cells from primary cell models and ART-suppressed individuals, suggesting these genes may play a role in the blocks to HIV transcription and splicing underlying latent infection. These genes may represent new targets for therapies designed to reactivate or silence latently-infected cells.
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PLoS pathogens
Authors: Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Authors: Chiang JM, Delgado C, Kaysen GA, Segal MR, Chertow GM, Johansen KL
International journal of molecular sciences
Authors: Yoshizaki K, Fukumoto S, Bikle DD, Oda Y
JACC. Heart failure
Authors: Felker GM, McMurray JJV, Cleland JG, O'Connor CM, Teerlink JR, Voors AA, Belohlavek J, Böhm M, Borentain M, Bueno H, Cole RT, DeSouza MM, Ezekowitz JA, Filippatos G, Lang NN, Kessler PD, Martinez FA, Mebazaa A, Metra M, Mosterd A, Pang PS, Ponikowski P, Sato N, Seiffert D, Ye J
TO REMOVE
Authors: Chen TK, Fitzpatrick J, Winkler CA, Binns-Roemer EA, Corona-Villalobos CP, Jaar BG, Sozio SM, Parekh RS, Estrella MM
HIV research & clinical practice
Authors: D'Souza G, Springer G, Gustafson D, Kassaye S, Alcaide ML, Ramirez C, Sharma A, Palella FJ, Tien PC, Detels R, Kempf MC, Lahiri CD, Rinaldo CR, French AL, Margolick JB, Adimora AA
Circulation
Authors: Emily R Cedarbaum, Yifei Ma, Rebecca Scherzer, Adaora A Adimora, Marcas Bamman, Mardge Cohen, Margaret A Fischl, Deborah R Gustafson, Kunihiro Matsushita, Igho Ofotokun, Michael Plankey, Eric C Seaberg, Anjali Sharma, Phyllis C Tien
Journal of the American College of Cardiology
Authors: Psotka MA, Abraham WT, Fiuzat M, Filippatos G, Lindenfeld J, Ahmad T, Bhatt AS, Carson PE, Cleland JGF, Felker GM, Januzzi JL, Kitzman DW, Leifer ES, Lewis EF, McMurray JJV, Mentz RJ, Solomon SD, Stockbridge N, Teerlink JR, Vaduganathan M, Vardeny O, Whellan DJ, Wittes J, Anker SD, O'Connor CM
Clinical chemistry
Authors: Ginsberg C, Hoofnagle AN, Katz R, Becker JO, Kritchevsky SB, Shlipak MG, Sarnak MJ, Ix JH
