American journal of physiology. Heart and circulatory physiology
Authors: Zhang J, Simpson PC, Jensen B
American journal of kidney diseases : the official journal of the National Kidney Foundation
Authors: Malhotra R, Katz R, Jotwani V, Agarwal A, Cohen DL, Cushman WC, Ishani A, Killeen AA, Kitzman DW, Oparil S, Papademetriou V, Parikh CR, Raphael KL, Rocco MV, Tamariz LJ, Whelton PK, Wright JT, Shlipak MG, Ix JH
American journal of kidney diseases : the official journal of the National Kidney Foundation
Authors: Bansal N, Zelnick LR, Soliman E, Anderson A, Christenson R, DeFilippi C, Deo R, Feldman HI, He J, Ky B, Kusek J, Lash J, Seliger S, Shafi T, Wolf M, Go AS, Shlipak MG
The Journal of clinical endocrinology and metabolism
Authors: Sharma S, Katz R, Bullen AL, Chaves PHM, de Leeuw PW, Kroon AA, Houben AJHM, Shlipak MG, Ix JH
Journal of the American Geriatrics Society
Authors: Jovanovich A, Ginsberg C, You Z, Katz R, Ambrosius WT, Berlowitz D, Cheung AK, Cho M, Lee AK, Punzi H, Rehman S, Roumie C, Supiano MA, Wright CB, Shlipak M, Ix JH, Chonchol M
BACKGROUND/OBJECTIVES
Chronic kidney disease (CKD) is associated with frailty. Fibroblast growth factor 23 (FGF23) is elevated in CKD and associated with frailty among non-CKD older adults and individuals with human immunodeficiency virus. Whether FGF23 is associated with frailty and falls in CKD is unknown.
DESIGN
Cross-sectional and longitudinal observational study.
SETTING
Systolic Blood Pressure Intervention Trial (SPRINT), a randomized trial evaluating standard (systolic blood pressure [SBP] <140 mm Hg) versus intensive (SBP <120 mm Hg) blood pressure lowering on cardiovascular and cognitive outcomes among older adults without diabetes mellitus.
PARTICIPANTS
A total of 2,376 participants with CKD (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m).
MEASUREMENTS
The exposure variable was intact FGF23. We used multinomial logistic regression to determine the cross-sectional association of intact FGF23 with frailty and Cox proportional hazards analysis to determine the longitudinal association with incident falls. Models were adjusted for demographics, comorbidities, randomization group, antihypertensives, eGFR, mineral metabolism markers, and frailty.
RESULTS
After adjustment, the odds ratio for prevalent frailty versus non-frailty per twofold higher FGF23 was 1.34 (95% confidence interval [CI] = 1.01-1.77). FGF23 levels in the highest quartile versus the lowest quartile demonstrated more than a twofold increased fall risk (hazard ratio [HR] = 2.32; 95% CI = 1.26-4.26), and the HR per twofold higher FGF23 was 1.99 (95% CI = 1.48-2.68).
CONCLUSION
Among SPRINT participants with CKD, FGF23 was associated with prevalent frailty and falls.
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Revue du Rhumatisme
Authors: R. Landewé, D. Van Der Heijde, M. Dougados, X. Baraliakos, F. Van den Bosch, K. Gaffney, L. Bauer, B. Hoepken, N. De Peyrecave, T. Kumke, L. Gensler
Revue du Rhumatisme
Authors: D. Van Der Heijde, L. Gensler, A. Deodhar, X. Baraliakos, D. Poddubnyy, A. Kivitz, M. Farmer, D. Baeten, N. Goldammer, J. Coarse, M. Oortgiesen, M. Dougados
Revue du Rhumatisme
Authors: A. Deodhar, D. Van Der Heijde, L. Gensler, T.H. Kim, W. Maksymowych, M. Ostergaard, D. Poddubnyy, H. Marzo-Ortega, L. Bessette, T. Tomita, G. Gallo, D.H. Adams, A. Leung, F. Zhao, M. Hojnik, H. Carlier, J. Sieper, M. Dougados
Revue du Rhumatisme
Authors: P. Goupille, J. Braun, R. Blanco, H. Marzo-Ortega, L. Gensler, F. Van den Bosch, H. Kameda, D. Poddubnyy, M. Van De Sande, A. Wiksten, B. Porter, S.G. Moreno, A. Shete, H. Richards, S. Haemmerle, A. Deodhar
Revue du Rhumatisme
Authors: M. Dougados, J. Sieper, X. Baraliakos, F. Van den Bosch, W. Maksymowych, J. Ermann, X. Li, G. Gallo, H. Carlier, L. Gensler, E. Lespessailles
