Journal of immunology (Baltimore, Md. : 1950) | Volume 136 of Issue 10
Authors: Lovett DH, Szamel M, Ryan JL, Sterzel RB, Gemsa D, Resch K
The proteins expressing interleukin 1 (IL 1) activity from rat peritoneal macrophages and cultured glomerular mesangial cells were compared after purification to apparent homogeneity. The purified IL 1 shared a number of biochemical features including m.w., charge, and specific activity. These findings were extended by the results of proteolytic peptide mapping, which revealed similar breakdown oligopeptides, confirming the close resemblance of these two IL 1 species produced by macrophages and mesangial cells. The purified mesangial cell IL 1 acts as an autocrine or paracrine growth factor. The local release of this cytokine may be an important factor in glomerular diseases characterized by mesangial proliferation and matrix expansion.
View on PubMed
Biochemistry
Authors: Bikle DD, Nemanic MK, Whitney JO, Elias PW
The Journal of clinical investigation
Authors: Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W
Journal of applied physiology (Bethesda, Md. : 1985)
Authors: Stanley WC, Gertz EW, Wisneski JA, Neese RA, Morris DL, Brooks GA
Immunobiology
Authors: Martin M, Lovett D, Resch K
Journal of cellular physiology
Authors: Bourguignon LY, Balazovich K, Suchard SJ, Hindsgaul O, Pierce M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Authors: Globus RK, Bikle DD, Halloran B, Morey-Holton E
Cardiovascular research
Authors: Karliner JS, Simpson PC, Honbo N, Woloszyn W
Endocrinology
Authors: Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E
Endocrinology
Authors: Nissenson RA, Mann E, Winer J, Teitelbaum AP, Arnaud CD