Publications

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Expert opinion on drug safety

The safety of sacubitril-valsartan for the treatment of chronic heart failure.

2017

Authors: Tyler JM, Teerlink JR

Clinical research in cardiology : official journal of the German Cardiac Society

Serelaxin in acute heart failure patients with and without atrial fibrillation: a secondary analysis of the RELAX-AHF trial.

2017

Authors: Filippatos G, Farmakis D, Metra M, Cotter G, Davison BA, Felker GM, Greenberg BH, Hua TA, Pang PS, Ponikowski P, Qian M, Severin TA, Voors AA, Teerlink JR

European heart journal

Agents with vasodilator properties in acute heart failure.

2017

Authors: Singh A, Laribi S, Teerlink JR, Mebazaa A

Inflammatory bowel diseases

P-305 SHIP1 Deficiency in Adult Inflammatory Bowel Disease Is Associated with Severe Crohn's Disease and Peripheral T Cell Reduction.

2017

Authors: Sandra Fernandes Denney, Neetu Srivastava, Frank Middleton, James Ryan, William Kerr

Psychiatric services (Washington, D.C.) | Volume 68 of Issue 6

Homeless Veterans' Use of Peer Mentors and Effects on Costs and Utilization in VA Clinics.

2017

Authors: Yoon J, Lo J, Gehlert E, Johnson EE, O'Toole TP

View Abstract

OBJECTIVES

The study compared health care utilization and costs among homeless veterans randomly assigned to peer mentors or usual care and described contacts with peer mentors.

METHODS

Homeless patients at four Department of Veterans Affairs clinics were randomly assigned to a peer mentor (N=195) or to usual care (N=180). Administrative data on utilization and costs over a six-month follow-up were combined with peer mentors' reports of patient contacts.

RESULTS

Most patients (87%) in the peer mentor group had at least one peer contact. Patients in this group spent the largest proportions of time discussing housing and health issues with peer mentors and had more outpatient encounters than those in usual care, although differences were not significant. No other between-group differences were found in utilization or costs.

CONCLUSIONS

Although significant impacts of peer mentors on health care patterns or costs were not detected, some patients had frequent contact with peer mentors.

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Journal of general internal medicine | Volume 32 of Issue 2

Seeing Wisely.

2017

Authors: Wheeler DJ, Mihara K, Chiovaro J

Journal of hospital medicine | Volume 12 of Issue 2

A shocking diagnosis.

2017

Authors: Prabhakaran A, Dhaliwal G, Schilf CR, Caughey GH, Pile J

Clinical journal of the American Society of Nephrology : CJASN

The Relation of Serum Potassium Concentration with Cardiovascular Events and Mortality in Community-Living Individuals.

2017

Authors: Hughes-Austin JM, Rifkin DE, Beben T, Katz R, Sarnak MJ, Deo R, Hoofnagle AN, Homma S, Siscovick DS, Sotoodehnia N, Psaty BM, de Boer IH, Kestenbaum B, Shlipak MG, Ix JH

European journal of heart failure

A multimarker multi-time point-based risk stratification strategy in acute heart failure: results from the RELAX-AHF trial.

2017

Authors: Demissei BG, Cotter G, Prescott MF, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Severin TM, Wang Y, Qian M, Teerlink JR, Metra M, Davison BA, Voors AA

AIDS (London, England) | Volume 31 of Issue 3

Sex differences in the association of HIV infection with hepatic steatosis.

2017

Authors: Kardashian A, Ma Y, Scherzer R, Price JC, Sarkar M, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC

View Abstract

BACKGROUND

Hepatic steatosis is increasing worldwide. Whether HIV and its associated metabolic perturbations exacerbate steatosis is unclear. Sex differences in adipose tissue distribution may also affect steatosis risk. We examined the contribution of HIV and sex to steatosis.

METHODS

Using MRI and spectroscopy, visceral adipose tissue (VAT) and liver fat fraction (LFF) were measured in 121 HIV-infected and 107 uninfected men and women without viral hepatitis. Differences in LFF by HIV status and sex were evaluated using multivariable linear regression, adjusting for demographic, lifestyle, VAT, homeostasis model assessment-estimated insulin resistance, and HIV-related factors.

RESULTS

HIV-infected women had lower LFF than uninfected women (demographic-adjusted mean: 1.9 vs. 3.1%; P = 0.028); LFF was similar in HIV-infected and uninfected men (4.6 vs. 4.1%; P = 0.78). HIV-infected and uninfected women had less VAT than men (median: 139 and 161 vs. 201 cm and 188 cm, respectively). After adjustment, HIV-infected women had 34% [95% confidence interval (CI): -54%, -5.5%] lower LFF than uninfected women, whereas there was little difference in men (-5.5%; 95% CI: -26%, 21%). Among HIV-infected persons, greater VAT and homeostasis model assessment-estimated insulin resistance were associated with greater LFF. HIV-related factors (CD4 cell count, HIV RNA level, or antiretroviral therapy use) had little association with LFF. Although HIV-infected men had 81% (95% CI: 32%, 148%) greater LFF than HIV-infected women, the association was attenuated after multivariable adjustment (25%; 95% CI: -9.1%, 73%).

CONCLUSION

Contrary to expectation, HIV infection is not associated with greater steatosis compared with uninfected adults. It is possible that less fat is stored in the liver to maintain subcutaneous fat (which is reduced in HIV) and the effect is magnified in HIV-infected women, who also have less VAT.

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