Publications | UCSF Department of Medicine at VA

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Preventive medicine reports

Acculturation and chronic kidney disease in the Hispanic community health study/study of Latinos (HCHS/SOL).

2018

Authors: Lora CM, Ricardo AC, Chen J, Cai J, Flessner M, Moncrieft A, Peralta C, Raij L, Rosas SE, Talavera GA, Daviglus ML, Lash JP

Gastrointestinal endoscopy | Volume 87 of Issue 4

Endoscopic submucosal dissection for nonpolypoid colorectal dysplasia in patients with inflammatory bowel disease: in medias res.

2018

Authors: Soetikno R, East J, Suzuki N, Uedo N, Matsumoto T, Watanabe K, Sanduleanu S, Sanchez-Yague A, Kaltenbach T

JAMA internal medicine

Breast Biopsy Intensity and Findings Following Breast Cancer Screening in Women With and Without a Personal History of Breast Cancer.

2018

Authors: Buist DSM, Abraham L, Lee CI, Lee JM, Lehman C, O'Meara ES, Stout NK, Henderson LM, Hill D, Wernli KJ, Haas JS, Tosteson ANA, Kerlikowske K, Onega T

Circulation Cardiovascular Quality and Outcomes

Abstract 192: Trends in Carotid Imaging in the VA Health System Following Choosing Wisely: An Interrupted Time Series Analysis.

2018

Authors: Timothy Anderson, Erin Madden, Sandy J Zhang, Danielle Mowery, Wendy Chapman, Salomeh Keyhani

TO REMOVE

FRI-120 Mechanisms of action of cortisol in steatotic and non-steatotic livers subjected to partial hepatectomy with vascular occlusion.

2018

Authors: E. Bujaldon, María E. Cornide-Petronio, E. Negrete-Sánchez, C.G. Ávalos De León, A.I. Álvarez-Mercado, J. Gulfo, Mónica Jiménez-Castro, F. Rotondo, J. Gracia-Sancho, C. Peralta

International journal of epidemiology

Cohort Profile: The Women's Interagency HIV Study (WIHS).

2018

Authors: Adimora AA, Ramirez C, Benning L, Greenblatt RM, Kempf MC, Tien PC, Kassaye SG, Anastos K, Cohen M, Minkoff H, Wingood G, Ofotokun I, Fischl MA, Gange S

JAMA internal medicine

Medicare Spending and Potential Savings on Brand-Name Drugs With Available Generic Substitutes Excluded by 2 Large Pharmacy Benefit Managers, 2012 Through 2015.

2018

Authors: Egilman AC, Wallach JD, Ross JS, Dhruva SS

JAMA internal medicine

Family History and Breast Cancer Risk Among Older Women in the Breast Cancer Surveillance Consortium Cohort.

2018

Authors: Braithwaite D, Miglioretti DL, Zhu W, Demb J, Trentham-Dietz A, Sprague B, Tice JA, Onega T, Henderson LM, Buist DSM, Ziv E, Walter LC, Kerlikowske K

Annals of the American Thoracic Society

Increasing the Resolution of Chronic Obstructive Pulmonary Disease Definition. Lessons from a Cohort with Remote but Extensive Exposure to Secondhand Tobacco Smoke.

2018

Authors: Arjomandi M, Zeng S, Blanc PD, Gold WM

Circulation. Heart failure | Volume 11 of Issue 4

Association of Biomarker Clusters With Cardiac Phenotypes and Mortality in Patients With HIV Infection.

2018

Authors: Scherzer R, Shah SJ, Secemsky E, Butler J, Grunfeld C, Shlipak MG, Hsue PY

View Abstract

BACKGROUND

Although individual cardiac biomarkers are associated with heart failure risk and all-cause mortality in HIV-infected individuals, their combined use for prediction has not been well studied.

METHODS AND RESULTS

Unsupervised k-means cluster analysis was performed blinded to the study outcomes in 332 HIV-infected participants on 8 biomarkers: ST2, NT-proBNP (N-terminal pro-B-type natriuretic peptide), hsCRP (high-sensitivity C-reactive protein), GDF-15 (growth differentiation factor 15), cystatin C, IL-6 (interleukin-6), D-dimer, and troponin. We evaluated cross-sectional associations of each cluster with diastolic dysfunction, pulmonary hypertension (defined as echocardiographic pulmonary artery systolic pressure ≥35 mm Hg), and longitudinal associations with all-cause mortality. The biomarker-derived clusters partitioned subjects into 3 groups. Cluster 3 (n=103) had higher levels of CRP, IL-6, and D-dimer (inflammatory phenotype). Cluster 2 (n=86) displayed elevated levels of ST2, NT-proBNP, and GDF-15 (cardiac phenotype). Cluster 1 (n=143) had lower levels of both phenotype-associated biomarkers. After multivariable adjustment for traditional and HIV-related risk factors, cluster 3 was associated with a 51% increased risk of diastolic dysfunction (95% confidence interval, 1.12-2.02), and cluster 2 was associated with a 67% increased risk of pulmonary hypertension (95% confidence interval, 1.04-2.68), relative to cluster 1. Over a median 6.9-year follow-up, 48 deaths occurred. Cluster 3 was independently associated with a 3.3-fold higher risk of mortality relative to cluster 1 (95% confidence interval, 1.3-8.1), and cluster 2 had a 3.1-fold increased risk (95% confidence interval, 1.1-8.4), even after controlling for diastolic dysfunction, pulmonary hypertension, left ventricular mass, and ejection fraction.

CONCLUSIONS

Serum biomarkers can be used to classify HIV-infected individuals into separate clusters for differentiating cardiopulmonary structural and functional abnormalities and can predict mortality independent of these structural and functional measures.

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