Publications

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Journal of geriatric oncology

P111 “NO ENERGY, ZIP”: A MIXED METHODS COMPARISON OF FUNCTIONAL DECLINE DURING IMMUNOTHERAPY, TARGETED THERAPY, AND/OR CHEMOTHERAPY IN OLDER ADULTS WITH NON-SMALL CELL LUNG CANCER (NSCLC).

2019

Authors: M.L. Wong, A.K. Smith, C. Miaskowski, V. Musinipally, H.J. Cohen, V. Lam, M. Mazor, C.J. Ursem, K. Loh, J.A. Cohen, D. Shumay, A.O. Levin, N. Dixit, J. Grandi, L.C. Walter

Journal of Clinical Oncology

Mixed methods comparison of functional decline during chemotherapy, immunotherapy (IO), and/or targeted therapy in older adults with non-small cell lung cancer (NSCLC).

2019

Authors: Melisa L. Wong, Alexander K. Smith, Christine Miaskowski, Vivek Musinipally, Harvey Jay Cohen, Vivian Lam, Melissa Mazor, Carling Jade Ursem, Kah Poh Loh, Jamie Cohen, Dianne Shumay, Anna Ordin Levin, Niharika Dixit, Janice Grandi, Louise Christie Walter

JAMA network open

Demographic Characteristics of Participants in Rheumatoid Arthritis Randomized Clinical Trials: A Systematic Review.

2019

Authors: Strait A, Castillo F, Choden S, Li J, Whitaker E, Falasinnu T, Schmajuk G, Yazdany J

JAMA network open

Association of Receipt of Positron Emission Tomography-Computed Tomography With Non-Small Cell Lung Cancer Mortality in the Veterans Affairs Health Care System.

2019

Authors: Vella M, Meyer CS, Zhang N, Cohen BE, Whooley MA, Wang S, Hope MD

JAMA internal medicine

An Alternative to Sodium Polystyrene Sulfonate and Patiromer for the Treatment of Hyperkalemia-Reply.

2019

Authors: Grady D, Parks M

Clinical and translational gastroenterology

Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes.

2019

Authors: Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS, Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S

JAMA network open | Volume 2 of Issue 11

Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis.

2019

Authors: Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D

View Abstract

Importance

Marijuana use is common and growing in the United States amid a trend toward legalization. Exposure to tobacco smoke is a well-described preventable cause of many cancers; the association of marijuana use with the development of cancer is not clear.

Objective

To assess the association of marijuana use with cancer development.

Data Sources

A search of PubMed, Embase, PsycINFO, MEDLINE, and the Cochrane Library was conducted on June 11, 2018, and updated on April 30, 2019. A systematic review and meta-analysis of studies published from January 1, 1973, to April 30, 2019, and references of included studies were performed, with data analyzed from January 2 through October 4, 2019.

Study Selection

English-language studies involving adult marijuana users and reporting cancer development. The search strategy contained the following 2 concepts linked together with the AND operator: marijuana OR marihuana OR tetrahydrocannabinol OR cannabinoid OR cannabis; AND cancer OR malignancy OR carcinoma OR tumor OR neoplasm.

Data Extraction and Synthesis

Two reviewers independently reviewed titles, abstracts, and full-text articles; 3 reviewers independently assessed study characteristics and graded evidence strength by consensus.

Main Outcomes and Measures

Rates of cancer in marijuana users, with ever use defined as at least 1 joint-year exposure (equivalent to 1 joint per day for 1 year), compared with nonusers. Meta-analysis was conducted if there were at least 2 studies of the same design addressing the same cancer without high risk of bias when heterogeneity was low to moderate for the following 4 cancers: lung, head and neck squamous cell carcinoma, oral squamous cell carcinoma, and testicular germ cell tumor (TGCT), with comparisons expressed as odds ratios (ORs) with 95% CIs.

Results

Twenty-five English-language studies (19 case-control, 5 cohort, and 1 cross-sectional) were included; few studies (n = 2) were at low risk of bias. In pooled analysis of case-control studies, ever use of marijuana was not associated with head and neck squamous cell carcinoma or oral cancer. In pooled analysis of 3 case-control studies, more than 10 years of marijuana use (joint-years not reported) was associated with TGCT (OR, 1.36; 95% CI, 1.03-1.81; P = .03; I2 = 0%) and nonseminoma TGCT (OR, 1.85; 95% CI, 1.10-3.11; P = .04; I2 = 0%). Evaluations of ever use generally found no association with cancers, but exposure levels were low and poorly defined. Findings for lung cancer were mixed, confounded by few marijuana-only smokers, poor exposure assessment, and inadequate adjustment; meta-analysis was not performed for several outcomes.

Conclusions and Relevance

Low-strength evidence suggests that smoking marijuana is associated with developing TGCT; its association with other cancers and the consequences of higher levels of use are unclear. Long-term studies in marijuana-only smokers would improve understanding of marijuana's association with lung, oral, and other cancers.