Robert Owen, MD
Professor Emeritus
My clinical work includes gastroenterology, general internal medicine, intestinal infectious diseases, HIV infection and AIDS, travel medicine and medical effects of military occupational environmental exposures, especially in Persian Gulf, Afghanistan, Vietnam (Agent Orange) and Ionizing Radiation exposed veterans. I am also a Compensation & Pension examiner for the Department of Veterans Affairs.
Research Interests:
My work has involved delineation of the structure and function of Peyer's patches and other mucosal
lymphoid organs, using ultrastructure, immunohistology, morphometric analysis, and FACS analysis in
immunocompetent and immunodeficient animal models. Clinical research interests include diarrhea and
intestinal infections, identifying the role of opportunistic pathogens including Giardia, Cryptosporidia,
Microsporidia and Mycobacterium avium.
Education
Publications
Rusheen AE, Goyal A, Owen RL, Berning EM, Bothun DT, Giblon RE, Blaha CD, Welker KM, Huston J, Bennet KE, Oh Y, Fagan AJ, Lee KH. The development of ultra-high field MRI guidance technology for neuronavigation. Journal of neurosurgery 2022. PMID: 35334465
Owen RL, Grewal SS, Thompson JM, Hassan A, Lee KH, Klassen BT. Effectiveness of Thalamic Ventralis Oralis Anterior and Posterior Nuclei Deep Brain Stimulation for Posttraumatic Dystonia. Mayo Clinic proceedings. Innovations, quality & outcomes 2022. PMID: 35243206
Jundt MC, Owen RL, Thompson SM, Fleming CJ, Stockland AH, Andrews JC. MELD-Na?>?16 is associated with high peri-procedural and short-term mortality in patients with ruptured hepatocellular carcinoma treated with emergent transarterial embolization. Abdominal radiology (New York) 2021. PMID: 34633495
Barath AS, Rusheen AE, Rojas Cabrera JM, Price JB, Owen RL, Shin H, Jang DP, Blaha CD, Lee KH, Oh Y. Hypoxia-Associated Changes in Striatal Tonic Dopamine Release: Real-Time in vivo Measurements With a Novel Voltammetry Technique. Frontiers in neuroscience 2020. PMID: 32973432
Wang QP, Wu ZD, Wei J, Owen RL, Lun ZR. Human Angiostrongylus cantonensis: an update. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2011. PMID: 21725905
Fujimura Y, Haruma K, Owen RL. Bombesin prevents the atrophy of Peyer's patches and the dysfunction of M cells in rabbits receiving long-term parenteral nutrition. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2007. PMID: 17308247
Kageyama M, Nakatsuka K, Yamaguchi T, Owen RL, Shimada T. Ocular defense mechanisms with special reference to the demonstration and functional morphology of the conjunctiva-associated lymphoid tissue in Japanese monkeys. Archives of histology and cytology 2006. PMID: 17372387
Schmucker DL, Owen RL, Outenreath R, Thoreux K. Basis for the age-related decline in intestinal mucosal immunity. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2003. PMID: 14768948
Fujimura Y, Owen RL. Tacrolimus (FK506) and cyclosporine reduce the uptake and transport of particles into rabbit Peyer's patches. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2002. PMID: 11965030
Schmucker DL, Thoreux K, Owen RL. Aging impairs intestinal immunity. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2001. PMID: 11470129
Thoreux K, Owen RL, Schmucker DL. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2000. PMID: 11012768
Owen RL. Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1999. PMID: 10381861
Owen RL. New perspectives on the pathogenesis of Cryptosporidium biliary disease. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1998. PMID: 9755257
Koch J, Owen RL. Small intestine pathogens in AIDS: conventional and opportunistic. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1998. PMID: 9730937
Lüthen R, Owen RL, Sarbia M, Grendell JH, Niederau C. Premature trypsinogen activation during cerulein pancreatitis in rats occurs inside pancreatic acinar cells. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1998. PMID: 9667518
Owen RL. M cells as portals of entry for HIV. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1998. PMID: 9693315
Owen RL. Mid-life crisis for M cells. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1998. PMID: 9505877
Schmidt W, Schneider T, Heise W, Schulzke JD, Weinke T, Ignatius R, Owen RL, Zeitz M, Riecken EO, Ullrich R. Mucosal abnormalities in microsporidiosis. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1997. PMID: 9365763
Owen RL. Polymerase chain reaction of stool: a powerful tool for specific diagnosis and epidemiologic investigation of enteric microsporidia infections. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1997. PMID: 9143615
Davis IC, Owen RL. The immunopathology of M cells. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1997. PMID: 9144863
Schmucker DL, Heyworth MF, Owen RL, Daniels CK. Impact of aging on gastrointestinal mucosal immunity. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1996. PMID: 8654151
Fujimura Y, Owen RL. M cells as portals of infection: clinical and pathophysiological aspects. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1996. PMID: 8805077
Ichikawa S, Sreedharan SP, Owen RL, Goetzl EJ. Immunochemical localization of type I VIP receptor and NK-1-type substance P receptor in rat lung. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1995. PMID: 7537460
Ichikawa S, Sreedharan SP, Goetzl EJ, Owen RL. Immunohistochemical localization of peptidergic nerve fibers and neuropeptide receptors in Peyer's patches of the cat ileum. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 7536334
Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 7834600
Sandfort J, Hannemann A, Gelderblom H, Stark K, Owen RL, Ruf B. Enterocytozoon bieneusi infection in an immunocompetent patient who had acute diarrhea and who was not infected with the human immunodeficiency virus. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 7811871
Owen RL. Microsporidia cause human disease: evidence by subtraction. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 7986419
Owen RL. M cells--entryways of opportunity for enteropathogens. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 8006602
Chui DW, Owen RL. AIDS and the gut. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 8054532
Kato T, Owen RL. Absence of EGF receptors and of EGF uptake in Peyer's patch dome epithelium. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1994. PMID: 7709839
Ohtsuka A, Piazza AJ, Ermak TH, Owen RL. Correlation of extracellular matrix components with the cytoarchitecture of mouse Peyer's patches. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1992. PMID: 1423508
Weber R, Bryan RT, Owen RL, Wilcox CM, Gorelkin L, Visvesvara GS. Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. The Enteric Opportunistic Infections Working Group. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1992. PMID: 1370122
Bryan RT, Cali A, Owen RL, Spencer HC. Microsporidia: opportunistic pathogens in patients with AIDS. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1991. PMID: 1893116
Owen RL, Piazza AJ, Ermak TH. Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1991. PMID: 1984672
Cali A, Owen RL. Intracellular development of Enterocytozoon, a unique microsporidian found in the intestine of AIDS patients. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1990. PMID: 2319490
Walker RI, Owen RL. Intestinal barriers to bacteria and their toxins. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1990. PMID: 2184739
Owen RL, Ermak TH. Structural specializations for antigen uptake and processing in the digestive tract. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1990. PMID: 2205936
Ermak TH, Steger HJ, Strober S, Owen RL. M cells and granular mononuclear cells in Peyer's patch domes of mice depleted of their lymphocytes by total lymphoid irradiation. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1989. PMID: 2923183
Pappo J, Owen RL. Absence of secretory component expression by epithelial cells overlying rabbit gut-associated lymphoid tissue. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1988. PMID: 2458985
Ermak TH, Steger HJ, Owen RL, Strober S. Depletion and repopulation of lymphocytes in Peyer's patches of mice after total lymphoid irradiation. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1988. PMID: 2903270
Pappo J, Steger HJ, Owen RL. Differential adherence of epithelium overlying gut-associated lymphoid tissue. An ultrastructural study. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1988. PMID: 3379916
Ermak TH, Steger HJ, Owen RL, Heyworth MF. Modulation of lymphocyte subsets in Peyer's patches of mice treated with monoclonal antibody against helper T-cells. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1988. PMID: 2964470
Owen RL, Cray WC, Ermak TH, Pierce NF. Bacterial characteristics and follicle surface structure: their roles in Peyer's patch uptake and transport of Vibrio cholerae. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1988. PMID: 3254071
Ermak TH, Owen RL. Phenotype and distribution of T lymphocytes in Peyer's patches of athymic mice. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1987. PMID: 3319975
Owen RL, Jones AL. Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1974. PMID: 4810912
Owen RL, Hill JL. Rectal and pharyngeal gonorrhea in homosexual men. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 1972. PMID: 4623385