Publications

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American journal of public health

Estimated deaths attributable to social factors in the United States.

2011

Authors: Galea S, Tracy M, Hoggatt KJ, Dimaggio C, Karpati A

Archives of internal medicine | Volume 171 of Issue 16

Opioids for chronic pain.

2011

Authors: Grady D, Berkowitz SA, Katz MH

The journals of gerontology. Series A, Biological sciences and medical sciences

Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the Cardiovascular Health Study All Stars study.

2011

Authors: Kizer JR, Arnold AM, Jenny NS, Cushman M, Strotmeyer ES, Ives DG, Ding J, Kritchevsky SB, Chaves PH, Hirsch CH, Newman AB

Hemodialysis international. International Symposium on Home Hemodialysis

Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.

2011

Authors: Dubin R, Owens C, Gasper W, Ganz P, Johansen K

Journal of general internal medicine

Reducing barriers to mental health and social services for Iraq and Afghanistan veterans: outcomes of an integrated primary care clinic.

2011

Authors: Seal KH, Cohen G, Bertenthal D, Cohen BE, Maguen S, Daley A

Circulation

Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study.

2011

Authors: Kawut SM, Lima JA, Barr RG, Chahal H, Jain A, Tandri H, Praestgaard A, Bagiella E, Kizer JR, Johnson WC, Kronmal RA, Bluemke DA

Journal of the American Geriatrics Society

A clinical index to stratify hospitalized older adults according to risk for new-onset disability.

2011

Authors: Mehta KM, Pierluissi E, Boscardin WJ, Kirby KA, Walter LC, Chren MM, Palmer RM, Counsell SR, Landefeld CS

The New England journal of medicine

Clinical problem-solving. A recurrent problem.

2011

Authors: Vikram HR, Dhaliwal G, Saint S, Simpson CB

Digestive diseases and sciences | Volume 56 of Issue 8

Retreatment of hepatitis C with consensus interferon and ribavirin after nonresponse or relapse to pegylated interferon and ribavirin: a national VA clinical practice study.

2011

Authors: Yee HS, Currie SL, Tortorice K, Cozen M, Shen H, Chapman S, Cunningham F, Monto A

BACKGROUND

Studies of the retreatment with consensus interferon (CIFN) and ribavirin (RBV) of hepatitis C virus (HCV)-infected patients who failed prior pegylated interferon alfa/ribavirin (PEG-IFN/RBV) have found quite variable efficacy and tolerability of this therapy. As such, CIFN/RBV use and efficacy in clinical practice were evaluated within the Department of Veterans Affairs (VA), the largest national, integrated system for HCV care.

AIMS

The purpose of this study was to determine rates of sustained virologic response (SVR) and patterns of CIFN/RBV use in the VA. Methods included retrospective review of national VA data in HCV-infected patients who had previously failed≥12 weeks of PEG-IFN/RBV and were prescribed CIFN/RBV between October 1, 2003 and September 30, 2006.

RESULTS

A total of 597 patients met the study criteria. CIFN was primarily dosed as 15 mcg subcutaneously daily combined with standard doses of RBV. Mean treatment duration was 21 weeks; CIFN was discontinued within 4 weeks in 24%. Hematological growth factors were used in 49%. Post-treatment viral loads were available in 385 patients. SVR to CIFN/RBV was achieved in 11%, and was significantly higher in prior PEG-IFN/RBV relapsers compared with nonresponders (31% vs. 6%, respectively; P<0.0001). A 2-log10 or greater drop in HCV RNA after 24 weeks of PEG-IFN/RBV was a predictor of subsequent SVR to CIFN/RBV.

CONCLUSIONS

CIFN/RBV was used frequently in clinical practice for retreatment of PEG-IFN/RBV. In this setting, early treatment discontinuation was common. Overall SVR was low, although response was significantly better in prior PEG-IFN/RBV relapsers and those who had a 2-log(10) or greater decline than in nonresponders.

The American journal of medicine

Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies.

2011

Authors: Yu EW, Bauer SR, Bain PA, Bauer DC