Publications

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European journal of endocrinology

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

2013

Authors: Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS

Urology

Lower urinary tract dysfunction in male Iraq and Afghanistan war veterans: association with mental health disorders: a population-based cohort study.

2013

Authors: Breyer BN, Cohen BE, Bertenthal D, Rosen RC, Neylan TC, Seal KH

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

A novel mouse model of trauma induced heterotopic ossification.

2013

Authors: Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B

Retrovirology

Expression profile of host restriction factors in HIV-1 elite controllers.

2013

Authors: Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK

Transplantation | Volume 96 of Issue 7

Podocyte effacement closely links to suPAR levels at time of posttransplantation focal segmental glomerulosclerosis occurrence and improves with therapy.

2013

Authors: Alachkar N, Wei C, Arend LJ, Jackson AM, Racusen LC, Fornoni A, Burke G, Rabb H, Kakkad K, Reiser J, Estrella MM

View Abstract

BACKGROUND

Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS.

METHODS

We conducted a retrospective study of 25 adults with posttransplantation FSGS. We investigated the relationship between suPAR levels and podocyte changes and the impact of therapy on podocyte structure. We assessed response to therapy by improvement in proteinuria, allograft function, and resolution of histologic changes.

RESULTS

A median (interquartile range) of 15 (10-23) plasmapheresis sessions was administered; 13 of the subjects also received rituximab. Median pretreatment suPAR levels were higher among those with severe (≥75%) versus those with mild (≤25%) podocyte foot process effacement (13,030 vs. 4806 pg/mL; P=0.02). Overall, mean±SD of proteinuria improved from 5.1±3.8 to 2.1±2.8 mg/dL (P=0.003), mean podocyte effacement decreased from 57%±33% to 22%±22% (P=0.0001), estimated glomerular filtration rates increased from median (interquartile range) of 32.9 (20.6-44.2) to 39.3 (28.8-63.4; P<0.0001), and suPAR levels decreased from a median of 6.781 to 4.129 pg/mL (P=0.02) with therapy.

CONCLUSIONS

Podocyte effacement is the first pathologic manifestation of FSGS after transplantation. The degree of podocyte effacement correlates with suPAR levels at time of diagnosis. Response to therapy results in significant reduction of suPAR levels and complete or significant improvement of podocyte effacement.

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The journals of gerontology. Series A, Biological sciences and medical sciences

Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study.

2013

Authors: Whitson HE, Arnold AM, Yee LM, Mukamal KJ, Kizer JR, Djousse L, Ix JH, Siscovick D, Tracy RP, Thielke SM, Hirsch C, Newman AB, Zieman S

American journal of surgery

Upgrade of high-risk breast lesions detected on mammography in the Breast Cancer Surveillance Consortium.

2013

Authors: Menes TS, Rosenberg R, Balch S, Jaffer S, Kerlikowske K, Miglioretti DL

The journals of gerontology. Series A, Biological sciences and medical sciences

Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women.

2013

Authors: Zeki Al Hazzouri A, Vittinghoff E, Byers A, Covinsky K, Blazer D, Diem S, Ensrud KE, Yaffe K

The American journal of cardiology

Relations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults =65 years of age (from the Cardiovascular Health study).

2013

Authors: Karas MG, Benkeser D, Arnold AM, Bartz TM, Djousse L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, Mantzoros CS, Gottdiener JS, deFilippi CR, Kizer JR

The Journal of bone and joint surgery. American volume | Volume 95 of Issue 19

Quantitative and qualitative assessment of bone perfusion and arterial contributions in a patellar fracture model using gadolinium-enhanced magnetic resonance imaging: a cadaveric study.

2013

Authors: Lazaro LE, Wellman DS, Klinger CE, Dyke JP, Pardee NC, Sculco PK, Berkes MB, Helfet DL, Lorich DG

View Abstract

BACKGROUND

The purpose of the present study was to evaluate the anatomy and contribution of the patellar vascular supply and to quantify the effect of a transverse fracture on patellar perfusion.

METHODS

In twenty matched pairs of fresh-frozen cadaveric knees, the superficial femoral artery, anterior tibialis artery, and posterior tibialis artery were cannulated. One side of each matched pair was randomly selected to undergo one of two osteotomies: (1) midpatellar osteotomy or (2) distal-pole osteotomy. For volumetric analysis, comparisons were performed between contrast-enhanced magnetic resonance images and precontrast magnetic resonance images as well as between osteotomized patellar bone fragments and the corresponding intact areas on the control side. We then injected a urethane polymer compound and dissected all specimens to examine extraosseous vascularity.

RESULTS

Magnetic resonance imaging demonstrated that the largest arterial contribution to the patella entered at the inferior pole in 100% of the specimens; in 80% of these specimens, the artery entered inferomedially. It also revealed an overall decrease in contrast enhancement in both transverse osteotomy groups, with an average reduction in enhancement in the proximal fragment of 36%.

CONCLUSIONS

If possible, surgical interventions about the knee should be carefully planned to preserve the peripatellar ring (the source of the entire patellar blood supply), especially the inferior patellar network. Distal-pole patellectomy should be avoided to retain vascularized bone at the reduced fracture site.

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