Anthony Baker, PhD
Education
Publications
Rupert C, López JE, Cortez-Toledo E, De la Cruz Cabrera O, Chesler NC, Simpson PC, Campbell SG, Baker AJ. Increased length-dependent activation of human engineered heart tissue after chronic a1A-adrenergic agonist treatment: testing a novel heart failure therapy. American journal of physiology. Heart and circulatory physiology 2023. PMID: 36637971
Beard DA, Marzban B, Li OY, Campbell KS, Janssen PML, Chesler NC, Baker AJ. Reduced cardiac muscle power with low ATP simulating heart failure. Biophysical journal 2022. PMID: 35918899
Izu L, Shimkunas R, Jian Z, Hegyi B, Kazemi-Lari M, Baker A, Shaw J, Banyasz T, Chen-Izu Y. Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2021. PMID: 34072584
Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach JK, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu LT, Chen-Izu Y. Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2021. PMID: 33601939
Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. Journal of biomedical materials research. Part A 2020. PMID: 32270584
Myagmar BE, Ismaili T, Swigart P, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC. Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Circulation research 2019. PMID: 31426700
Cowley PM, Roberts CR, Baker AJ. Monitoring the Health Status of Mice with Bleomycin-induced Lung Injury by Using Body Condition Scoring. 2019. PMID: 30808435
Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy NP, Dulam P, Lovett DH, Simpson PC, Baker AJ. Reversal of Right Ventricular failure by Chronic α1A-Subtype Adrenergic Agonist Therapy. American journal of physiology. Heart and circulatory physiology 2018. PMID: 30412439
Janssen PML, Canan BD, Kilic A, Whitson BA, Baker AJ. Human Myocardium Has a Robust a1A-Subtype Adrenergic Receptor Inotropic Response. 2018. PMID: 29923888
Pewowaruk RJ, Philip JL, Tewari SG, Chen CS, Nyaeme MS, Wang Z, Tabima DM, Baker AJ, Beard DA, Chesler NC. Multiscale Computational Analysis of Right Ventricular Mechanoenergetics. 2018. PMID: 30003251
Philip JL, Pewowaruk RJ, Chen CS, Tabima DM, Beard DA, Baker AJ, Chesler NC. Impaired Myofilament Contraction Drives Right Ventricular Failure Secondary to Pressure Overload: Model Simulations, Experimental Validation, and Treatment Predictions. 2018. PMID: 29997518
Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PloS one 2018. PMID: 29432443
Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. a1A-Subtype adrenergic agonist therapy for the failing right ventricle. Volume 313 of Issue 6. American journal of physiology. Heart and circulatory physiology 2017. PMID: 28822963
Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. Volume 30 of Issue 10. NMR in biomedicine 2017. PMID: 28708304
Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ. Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent". Circulation research 2017. PMID: 28596177
Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Volume 312 of Issue 6. American journal of physiology. Renal physiology 2017. PMID: 28331061
Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circulation research 2017. PMID: 28219977
Thomas RC, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PloS one 2016. PMID: 27258143
Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC. Basic to translational science 2016. PMID: 27453955
Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. The a1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Volume 309 of Issue 5. American journal of physiology. Heart and circulatory physiology 2015. PMID: 26116709
Chang AN, Battiprolu PK, Cowley PM, Chen G, Gerard RD, Pinto JR, Hill JA, Baker AJ, Kamm KE, Stull JT. Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo. The Journal of biological chemistry 2015. PMID: 25733667
Lovett DH, Chu C, Wang G, Ratcliffe MB, Baker AJ. A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium. Volume 5. Frontiers in physiology 2014. PMID: 25309453
Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Volume 307 of Issue 8. American journal of physiology. Heart and circulatory physiology 2014. PMID: 25128171
Baker AJ. Adrenergic signaling in heart failure: a balance of toxic and protective effects. 2014. PMID: 24623099
O'Connell TD, Jensen BC, Baker AJ, Simpson PC. Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacological reviews 2013. PMID: 24368739
Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. Volume 8 of Issue 7. PloS one 2013. PMID: 23874529
Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. 2013. PMID: 23523189
Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. Intraventricular and interventricular cellular heterogeneity of inotropic responses to a(1)-adrenergic stimulation. Volume 304 of Issue 7. American journal of physiology. Heart and circulatory physiology 2013. PMID: 23355341
Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. 2012. PMID: 22509168
Baker AJ. Refueling the heart: Using 2-deoxy-ATP to enhance cardiac contractility. 2011. PMID: 22001677
Oishi PE, Cholsiripunlert S, Gong W, Baker AJ, Bernstein HS. Myo-mechanical analysis of isolated skeletal muscle. Journal of visualized experiments : JoVE 2011. PMID: 21403622
Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. Journal of cellular biochemistry 2010. PMID: 20186881
Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. American journal of physiology. Heart and circulatory physiology 2009. PMID: 20035030
Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. 2009. PMID: 20016753
McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Volume 294 of Issue 1. American journal of physiology. Heart and circulatory physiology 2007. PMID: 17965283
Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Volume 358 of Issue 1. Biochemical and biophysical research communications 2007. PMID: 17475219
Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ. Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16731650
O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2006. PMID: 16585965
Turcato S, Turnbull L, Wang GY, Honbo N, Simpson PC, Karliner JS, Baker AJ. Ischemic preconditioning depends on age and gender. Basic research in cardiology 2006. PMID: 16450074
Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2005. PMID: 16243914
Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Volume 69 of Issue 3. Cardiovascular research 2005. PMID: 16183043
McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2005. PMID: 15797971
McCloskey DT, Turnbull L, Swigart P, O'Connell TD, Simpson PC, Baker AJ. Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice. Journal of molecular and cellular cardiology 2003. PMID: 14519431
Turnbull L, McCloskey DT, O'Connell TD, Simpson PC, Baker AJ. Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. American journal of physiology. Heart and circulatory physiology 2002. PMID: 12595294
McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC, Baker AJ. Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice. Journal of molecular and cellular cardiology 2002. PMID: 12234770
Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2001. PMID: 11247776
Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2000. PMID: 10781088
Halow JM, Figueredo VM, Shames DM, Camacho SA, Baker AJ. Role of slowed Ca(2+) transient decline in slowed relaxation during myocardial ischemia. 1999. PMID: 10471357
Baker AJ. Cellular and extracellular mechanisms causing myocardial stunning. Journal of the American College of Cardiology 1999. PMID: 10440179
Baker AJ, Figueredo VM, Keung EC, Camacho SA. Ca2+ regulates the kinetics of tension development in intact cardiac muscle. 1998. PMID: 9724275
Figueredo VM, Chang KC, Baker AJ, Camacho SA. Chronic alcohol-induced changes in cardiac contractility are not due to changes in the cytosolic Ca2+ transient. 1998. PMID: 9688904
Baker AJ, Weiner MW. Force decline during muscle relaxation promotes calcium release to the cytosol. 1997. PMID: 9252445
Shames DM, Baker AJ, Weiner MW, Camacho SA. Ca(2+)-force relationship of frog skeletal muscle: a dynamic model for parameter estimation. 1996. PMID: 8997209
Schreur JH, Figueredo VM, Miyamae M, Shames DM, Baker AJ, Camacho SA. Cytosolic and mitochondrial [Ca2+] in whole hearts using indo-1 acetoxymethyl ester: effects of high extracellular Ca2+. 1996. PMID: 8744296
Zhao L, Pate E, Baker AJ, Cooke R. The myosin catalytic domain does not rotate during the working power stroke. 1995. PMID: 8519999
Baker AJ, Brandes R, Weiner MW. Effects of intracellular acidosis on Ca2+ activation, contraction, and relaxation of frog skeletal muscle. 1995. PMID: 7840160
Miller RG, Carson PJ, Moussavi RS, Green A, Baker A, Boska MD, Weiner MW. Factors which influence alterations of phosphates and pH in exercising human skeletal muscle: measurement error, reproducibility, and effects of fasting, carbohydrate loading, and metabolic acidosis. 1995. PMID: 7799999
Baker AJ, Brandes R, Schreur JH, Camacho SA, Weiner MW. Protein and acidosis alter calcium-binding and fluorescence spectra of the calcium indicator indo-1. 1994. PMID: 7819496
Baker AJ, Carson PJ, Miller RG, Weiner MW. Metabolic and nonmetabolic components of fatigue monitored with 31P-NMR. 1994. PMID: 8065387
Baker AJ, Brandes R, Schendel TM, Trocha SD, Miller RG, Weiner MW. Energy use by contractile and noncontractile processes in skeletal muscle estimated by 31P-NMR. 1994. PMID: 8166246
Brandes R, Figueredo VM, Camacho SA, Baker AJ, Weiner MW. Investigation of factors affecting fluorometric quantitation of cytosolic [Ca2+] in perfused hearts. 1993. PMID: 8298028
Brandes R, Figueredo VM, Camacho SA, Baker AJ, Weiner MW. Quantitation of cytosolic [Ca2+] in whole perfused rat hearts using Indo-1 fluorometry. 1993. PMID: 8298027
Baker AJ, Kostov KG, Miller RG, Weiner MW. Slow force recovery after long-duration exercise: metabolic and activation factors in muscle fatigue. 1993. PMID: 8335559
Baker AJ, Longuemare MC, Brandes R, Weiner MW. Intracellular tetanic calcium signals are reduced in fatigue of whole skeletal muscle. 1993. PMID: 8460665
Gordon L, Levinsohn DG, Borowsky CD, Manojlovic RD, Sessler DI, Weiner MW, Baker AJ. Improved preservation of skeletal muscle in amputated limbs using pulsatile hypothermic perfusion with University of Wisconsin solution. A preliminary study. 1992. PMID: 1429791
Baker AJ, Carson PJ, Green AT, Miller RG, Weiner MW. Influence of human muscle length on energy transduction studied by 31P-NMR. 1992. PMID: 1506363
Miller RG, Carson PJ, Moussavi RS, Green AT, Baker AJ, Weiner MW. Fatigue and myalgia in AIDS patients. Neurology 1991. PMID: 1922802
Weiner MW, Moussavi RS, Baker AJ, Boska MD, Miller RG. Constant relationships between force, phosphate concentration, and pH in muscles with differential fatigability. Neurology 1990. PMID: 2247239
Baker AJ, Carson PJ, Miller RG, Weiner MW. Investigations of muscle bioenergetics with 31P NMR. Investigative radiology 1989. PMID: 2691438