Anthony Baker, PhD

Education
1986 - Biophysics, University of California, San Francisco
PhD, 1984 - Physiology, University of Bristol
BA, 1979 - Biology, University of York
Publications

  1. Baker AJ, Li OY, Ježek F, Simpson PC, Chesler NC, Beard DA. Ca 2+ increases cardiac muscle viscoelasticity independent of active force development. bioRxiv : the preprint server for biology 2025. PMID: 40060454


  2. Ježek F, Baker AJ, Nordsletten DA, Beard DA. Theoretical Analysis of Power-Law Stress Relaxation and Calcium-Dependent Passive Mechanics in Cardiac Muscle. bioRxiv : the preprint server for biology 2025. PMID: 40060459


  3. Rupert C, López JE, Cortez-Toledo E, De la Cruz Cabrera O, Chesler NC, Simpson PC, Campbell SG, Baker AJ. Increased length-dependent activation of human engineered heart tissue after chronic a1A-adrenergic agonist treatment: testing a novel heart failure therapy. American journal of physiology. Heart and circulatory physiology 2023. PMID: 36637971


  4. Beard DA, Marzban B, Li OY, Campbell KS, Janssen PML, Chesler NC, Baker AJ. Reduced cardiac muscle power with low ATP simulating heart failure. Biophysical journal 2022. PMID: 35918899


  5. Izu L, Shimkunas R, Jian Z, Hegyi B, Kazemi-Lari M, Baker A, Shaw J, Banyasz T, Chen-Izu Y. Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2021. PMID: 34072584


  6. Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach JK, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu LT, Chen-Izu Y. Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2021. PMID: 33601939


  7. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. Journal of biomedical materials research. Part A 2020. PMID: 32270584


  8. Myagmar BE, Ismaili T, Swigart P, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC. Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Circulation research 2019. PMID: 31426700


  10. Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy NP, Dulam P, Lovett DH, Simpson PC, Baker AJ. Reversal of Right Ventricular failure by Chronic α1A-Subtype Adrenergic Agonist Therapy. American journal of physiology. Heart and circulatory physiology 2018. PMID: 30412439


  11. Janssen PML, Canan BD, Kilic A, Whitson BA, Baker AJ. Human Myocardium Has a Robust a1A-Subtype Adrenergic Receptor Inotropic Response. 2018. PMID: 29923888


  12. Pewowaruk RJ, Philip JL, Tewari SG, Chen CS, Nyaeme MS, Wang Z, Tabima DM, Baker AJ, Beard DA, Chesler NC. Multiscale Computational Analysis of Right Ventricular Mechanoenergetics. 2018. PMID: 30003251


  14. Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PloS one 2018. PMID: 29432443


  15. Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. a1A-Subtype adrenergic agonist therapy for the failing right ventricle. Volume 313 of Issue 6. American journal of physiology. Heart and circulatory physiology 2017. PMID: 28822963


  16. Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. Volume 30 of Issue 10. NMR in biomedicine 2017. PMID: 28708304


  18. Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Volume 312 of Issue 6. American journal of physiology. Renal physiology 2017. PMID: 28331061


  19. Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circulation research 2017. PMID: 28219977


  20. Thomas RC, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PloS one 2016. PMID: 27258143


  21. Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC. Basic to translational science 2016. PMID: 27453955


  22. Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. The a1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Volume 309 of Issue 5. American journal of physiology. Heart and circulatory physiology 2015. PMID: 26116709


  23. Chang AN, Battiprolu PK, Cowley PM, Chen G, Gerard RD, Pinto JR, Hill JA, Baker AJ, Kamm KE, Stull JT. Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo. The Journal of biological chemistry 2015. PMID: 25733667


  24. Lovett DH, Chu C, Wang G, Ratcliffe MB, Baker AJ. A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium. Volume 5. Frontiers in physiology 2014. PMID: 25309453


  25. Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Volume 307 of Issue 8. American journal of physiology. Heart and circulatory physiology 2014. PMID: 25128171


  27. O'Connell TD, Jensen BC, Baker AJ, Simpson PC. Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacological reviews 2013. PMID: 24368739


  28. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. Volume 8 of Issue 7. PloS one 2013. PMID: 23874529


  29. Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. 2013. PMID: 23523189


  30. Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. Intraventricular and interventricular cellular heterogeneity of inotropic responses to a(1)-adrenergic stimulation. Volume 304 of Issue 7. American journal of physiology. Heart and circulatory physiology 2013. PMID: 23355341


  31. Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. 2012. PMID: 22509168


  33. Oishi PE, Cholsiripunlert S, Gong W, Baker AJ, Bernstein HS. Myo-mechanical analysis of isolated skeletal muscle. Journal of visualized experiments : JoVE 2011. PMID: 21403622


  34. Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. Journal of cellular biochemistry 2010. PMID: 20186881


  35. Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ. Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. American journal of physiology. Heart and circulatory physiology 2009. PMID: 20035030


  36. Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. 2009. PMID: 20016753


  37. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Volume 294 of Issue 1. American journal of physiology. Heart and circulatory physiology 2007. PMID: 17965283


  38. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Volume 358 of Issue 1. Biochemical and biophysical research communications 2007. PMID: 17475219


  39. Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ. Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16731650


  40. O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2006. PMID: 16585965


  41. Turcato S, Turnbull L, Wang GY, Honbo N, Simpson PC, Karliner JS, Baker AJ. Ischemic preconditioning depends on age and gender. Basic research in cardiology 2006. PMID: 16450074


  42. Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2005. PMID: 16243914


  43. Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Volume 69 of Issue 3. Cardiovascular research 2005. PMID: 16183043


  44. McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2005. PMID: 15797971


  45. McCloskey DT, Turnbull L, Swigart P, O'Connell TD, Simpson PC, Baker AJ. Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice. Journal of molecular and cellular cardiology 2003. PMID: 14519431


  46. Turnbull L, McCloskey DT, O'Connell TD, Simpson PC, Baker AJ. Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. American journal of physiology. Heart and circulatory physiology 2002. PMID: 12595294


  47. McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC, Baker AJ. Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice. Journal of molecular and cellular cardiology 2002. PMID: 12234770


  48. Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2001. PMID: 11247776


  49. Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. "HIV within the House Ball Community and the Promise of Community-based Social Structures for Intervention and Support" 2000. PMID: 10781088


  50. Halow JM, Figueredo VM, Shames DM, Camacho SA, Baker AJ. Role of slowed Ca(2+) transient decline in slowed relaxation during myocardial ischemia. 1999. PMID: 10471357


  51. Baker AJ. Cellular and extracellular mechanisms causing myocardial stunning. Journal of the American College of Cardiology 1999. PMID: 10440179


  52. Baker AJ, Figueredo VM, Keung EC, Camacho SA. Ca2+ regulates the kinetics of tension development in intact cardiac muscle. 1998. PMID: 9724275


  55. Shames DM, Baker AJ, Weiner MW, Camacho SA. Ca(2+)-force relationship of frog skeletal muscle: a dynamic model for parameter estimation. 1996. PMID: 8997209


  56. Schreur JH, Figueredo VM, Miyamae M, Shames DM, Baker AJ, Camacho SA. Cytosolic and mitochondrial [Ca2+] in whole hearts using indo-1 acetoxymethyl ester: effects of high extracellular Ca2+. 1996. PMID: 8744296


  57. Zhao L, Pate E, Baker AJ, Cooke R. The myosin catalytic domain does not rotate during the working power stroke. 1995. PMID: 8519999


  60. Baker AJ, Brandes R, Schreur JH, Camacho SA, Weiner MW. Protein and acidosis alter calcium-binding and fluorescence spectra of the calcium indicator indo-1. 1994. PMID: 7819496


  61. Baker AJ, Carson PJ, Miller RG, Weiner MW. Metabolic and nonmetabolic components of fatigue monitored with 31P-NMR. 1994. PMID: 8065387


  62. Baker AJ, Brandes R, Schendel TM, Trocha SD, Miller RG, Weiner MW. Energy use by contractile and noncontractile processes in skeletal muscle estimated by 31P-NMR. 1994. PMID: 8166246


  63. Brandes R, Figueredo VM, Camacho SA, Baker AJ, Weiner MW. Investigation of factors affecting fluorometric quantitation of cytosolic [Ca2+] in perfused hearts. 1993. PMID: 8298028


  64. Brandes R, Figueredo VM, Camacho SA, Baker AJ, Weiner MW. Quantitation of cytosolic [Ca2+] in whole perfused rat hearts using Indo-1 fluorometry. 1993. PMID: 8298027


  66. Baker AJ, Longuemare MC, Brandes R, Weiner MW. Intracellular tetanic calcium signals are reduced in fatigue of whole skeletal muscle. 1993. PMID: 8460665


  67. Gordon L, Levinsohn DG, Borowsky CD, Manojlovic RD, Sessler DI, Weiner MW, Baker AJ. Improved preservation of skeletal muscle in amputated limbs using pulsatile hypothermic perfusion with University of Wisconsin solution. A preliminary study. 1992. PMID: 1429791


  68. Baker AJ, Carson PJ, Green AT, Miller RG, Weiner MW. Influence of human muscle length on energy transduction studied by 31P-NMR. 1992. PMID: 1506363


  69. Miller RG, Carson PJ, Moussavi RS, Green AT, Baker AJ, Weiner MW. Fatigue and myalgia in AIDS patients. Neurology 1991. PMID: 1922802


  70. Weiner MW, Moussavi RS, Baker AJ, Boska MD, Miller RG. Constant relationships between force, phosphate concentration, and pH in muscles with differential fatigability. Neurology 1990. PMID: 2247239


  71. Baker AJ, Carson PJ, Miller RG, Weiner MW. Investigations of muscle bioenergetics with 31P NMR. Investigative radiology 1989. PMID: 2691438